Journal: Polymers

Article Title: Bone Regeneration in SLS-Manufactured Resorbable 3D-Scaffolds—An Experimental Pilot Study in Minipigs

doi: 10.3390/polym17182498

Figure Lengend Snippet: Outline of the experimental setting: Hybridization of CaCO3/CaCO 3 &CaP and PLLA, scaffold production using SLS, implantation into minipigs for 4 weeks and 13 weeks.

Article Snippet: In brief, poly-L-lactic acid (PLLA) (Resomer L206 S, Evonik, Essen, Germany, inherent viscosity range 0.8–1.2 gL/g) granules and spherulite-shaped precipitated calcium carbonate—with and without CaP (calcium phosphate coating (4%)—were dry processed in an impact mill (NHS-1, Tokyo 143, Japan) at 6400 rpm, leading to an inclusion of the spherulites into the PLLA granules.

Techniques: Hybridization

Journal: Polymers

Article Title: Bone Regeneration in SLS-Manufactured Resorbable 3D-Scaffolds—An Experimental Pilot Study in Minipigs

doi: 10.3390/polym17182498

Figure Lengend Snippet: ( A ): cylindrical scaffold of 7 mm diameter and 5 mm height; ( B ): scaffold with 800 µm scaffold web thickness, bar: 1 mm; ( C ): scaffold with 1000 µm scaffold web thickness, bar: 1 mm; ( D ): PLLA-CaCO 3 scaffold, bar: 200 µm; ( E ): PLLA-CaCO 3 /CaP scaffold, a large number of unmelted polymer composite granules is attached to the scaffold surface as residuals after laser sintering, bar: 200 µm.

Article Snippet: In brief, poly-L-lactic acid (PLLA) (Resomer L206 S, Evonik, Essen, Germany, inherent viscosity range 0.8–1.2 gL/g) granules and spherulite-shaped precipitated calcium carbonate—with and without CaP (calcium phosphate coating (4%)—were dry processed in an impact mill (NHS-1, Tokyo 143, Japan) at 6400 rpm, leading to an inclusion of the spherulites into the PLLA granules.

Techniques: Polymer

Journal: Polymers

Article Title: Bone Regeneration in SLS-Manufactured Resorbable 3D-Scaffolds—An Experimental Pilot Study in Minipigs

doi: 10.3390/polym17182498

Figure Lengend Snippet: Representative cross-sections through the scaffolds, Alizarin–Methylene Blue stain (ar: 2000 µm): White arrows indicate bone ingrowth into the scaffolds from the defect walls. Upper row 4 weeks : ( A ): Group 1/PLLA-CaCO 3 scaffolds with 1000 µm scaffold web thickness (pore volume 69 mm 3 ); ( B ): Group 2/PLLA-CaCO 3 scaffolds with 800 µm scaffold web thickness, (pore volume 78 mm 3 ); ( C ): Group 3/PLLA-CaCO 3 /CaP scaffolds with 1000 µm scaffold web thickness, (pore volume 69 mm 3 ); ( D ): Group 4/PLLA-CaCO 3 /CaP scaffolds with 800 µm scaffold web thickness, (pore volume 78 mm 3 ). Lower row: 13 weeks ( E ): Group 1/PLLA-CaCO 3 scaffolds with 1000 µm scaffold web thickness (pore volume 69 mm 3 ); ( F ): Group 2/PLLA-CaCO 3 scaffolds with 800 µm scaffold web thickness (pore volume 78 mm 3 ); ( G ): Group 3/PLLA-CaCO 3 /CaP scaffolds with 1000 µm scaffold web thickness (pore volume 69 mm 3 ). White arrows indicate bone ingrowth into the scaffolds with almost complete pore fill. ( H ): Group 4/PLLA-CaCO 3 /CaP scaffolds with 800 µm scaffold web thickness, (pore volume 78 mm 3 ).

Article Snippet: In brief, poly-L-lactic acid (PLLA) (Resomer L206 S, Evonik, Essen, Germany, inherent viscosity range 0.8–1.2 gL/g) granules and spherulite-shaped precipitated calcium carbonate—with and without CaP (calcium phosphate coating (4%)—were dry processed in an impact mill (NHS-1, Tokyo 143, Japan) at 6400 rpm, leading to an inclusion of the spherulites into the PLLA granules.

Techniques: Staining

Journal: Polymers

Article Title: Bone Regeneration in SLS-Manufactured Resorbable 3D-Scaffolds—An Experimental Pilot Study in Minipigs

doi: 10.3390/polym17182498

Figure Lengend Snippet: Representative cross-sections through the scaffolds, peroxidase stain of osteocalcin (Bar: 1000 µm): Intense positive reactions for osteocalcin throughout the tissue grown into the scaffold volume (black asterisks). Upper row 4 weeks : ( A ): Group 1/PLLA-CaCO 3 scaffolds with 1000 µm scaffold web thickness (pore volume 69 mm 3 ); ( B ): Group 2/PLLA-CaCO 3 scaffolds with 800 µm scaffold web thickness, (pore volume 78 mm 3 ); ( C ): Group 3/PLLA-CaCO 3 /CaP scaffolds with 1000 µm scaffold web thickness, (pore volume 69 mm 3 ); ( D ): Group 4/PLLA-CaCO 3 /CaP scaffolds with 800 µm scaffold web thickness, (pore volume 78 mm 3 ). Lower Row: 13 weeks. Positive reaction for osteocalcin has decreased to small seams on the surface of the newly formed bone and the scaffold surface (black arrows). ( E ): Group 1/PLLA-CaCO 3 scaffolds with 1000 µm scaffold web thickness (pore volume 69 mm 3 ); ( F ): Group 2/PLLA-CaCO 3 scaffolds with 800 µm scaffold web thickness, (pore volume 78 mm 3 ); ( G ): Group 3/PLLA-CaCO 3 /CaP scaffolds with 1000 µm scaffold web thickness, (pore volume 69 mm 3 ); ( H ): Group 4/PLLA-CaCO 3 /CaP scaffolds with 800 µm scaffold web thickness, (pore volume 78 mm 3 ).

Article Snippet: In brief, poly-L-lactic acid (PLLA) (Resomer L206 S, Evonik, Essen, Germany, inherent viscosity range 0.8–1.2 gL/g) granules and spherulite-shaped precipitated calcium carbonate—with and without CaP (calcium phosphate coating (4%)—were dry processed in an impact mill (NHS-1, Tokyo 143, Japan) at 6400 rpm, leading to an inclusion of the spherulites into the PLLA granules.

Techniques: Staining